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KMID : 0882420110800050588
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Korean Journal of Medicine
2011 Volume.80 No. 5 p.588 ~ p.594
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A Case of Pulmonary Alveolar Proteinosis that Improved with GM-CSF Inhalation Therapy
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Chang Bok-Soon
Noh Jung-Won
Ok Chang-Soo
Lee Ga-Yeon
Sohn Seo-Young
Bang Sun-Ha
Chung Man-Pyo
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Abstract
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Pulmonary alveolar proteinosis (PAP) is a rare condition that is treated using whole lung lavage. A recent study suggested that granulocyte-macrophage colony stimulating factor (GM-CSF) plays roles in both the pathogenesis and treatment of PAP. We present a 69-year-old man with PAP who deteriorated despite bilateral whole lung lavage; that said, his symptoms, chest X-ray findings, and pulmonary function test improved after GM-CSF inhalation therapy over 12 months. GM-CSF therapy is an effective treatment modality for PAP.
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KEYWORD
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Pulmonary alveolar proteinosis, Bronchoalveolar lavage, GM-CSF
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